Euglycemia or normal blood sugar regulation is one of the proper functioning of pancreatic beta cell that ensure normal insulin secretion.
In glucose homeostasis, beta cell have a significant role. Loss of insulin secretion capacity leads to hyperglycemia.
For a certain cause, pancreatic beta cell may reduce insulin secretion.
Insulin resistance
amyloid deposition
Lipotoxicity
Mitochondrial dysfunction
ER stress
Inflamation
In terms of type two diabetes, the number of beta cell is reduces.
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